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Clinique's most famous fragrance, called Happy, is advertised as being "a hint of citrus, a wealth of flowers, a mix of emotions and a chic, modern, multi-layered sparkling floral." Happy is also available in other products. With the success of Happy, Clinique then went on to develop Happy into other sister fragrances, such as Happy To Be and Happy Heart. Clinique also introduced two Limited Edition Happy fragrances Happy Holiday and Happy In Bloom, the second of which is currently still available in shops. Other Clinique women's fragrances include Wrappings (which only appears during the holiday season) and Simply (currently being phased out).

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When the skin care and makeup company Clinique made its debut in 1968, the cosmetics brand changed America’s beauty landscape by using scientific language and clinical iconography at a time when highly perfumed, elaborately packaged creams dominated the high street. Through laboratories in the United States, Europe and Asia, and thanks to countless academic, medical and research relationships, Clinique is able to bring the best that science has to offer to all customers. Now Clinique have gone one step further in aligning itself with therapeutic imagery — and at the same time has raised the ante for beauty companies seeking affiliations with experts in the medical field. They announced the opening of the Clinique Skin Wellness Center by the Department of Dermatology at Weill Cornell Medical College. This place will be led by Dr. Richard Granstein, Chairman of the Depertment of Dermatology at Weill Cornell. It will exist to advance the understanding of skin from clinical, scientific and cosmetic points of view. Visionary in its concept, the Clinique Skin Wellness Center is both a physical space for patient services and education as well as a center without walls that fosters joint research, education and outreach programs. It is both a physical space for patient services and education, as well as a center without walls that fosters joint research and outreach programs.

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